Readers respond to classroom robots, soil erosion and more

Robot revolution?
Educational robots could help students learn new skills and good study habits. But researchers still have a lot to learn about the potential risks involved when young kids keep close company with such robots, Maria Temming reported in “Robots are becoming classroom tutors. But will they make the grade?” (SN: 2/16/19, p. 16).The story reminded reader A. Bogart of Isaac Asimov’s novel The Naked Sun, in which robots and humans live side by side. Asimov “raised the specter of some of the same issues with which scientists are now grappling,” Bogart wrote. Although Asimov had a positive view of science and innovation, all inventions are force multipliers, Bogart noted. “That means they can be used to multiply the effects of good and evil,” Bogart wrote. “Even at this early stage, it is well to think about negative impacts as well as positive ones.”
Dogged questions
Bone fragments of dogs and other animals unearthed from Shubayqa 6, the site of an ancient settlement in Jordan, suggest that dogs may have helped humans devise new ways of hunting small game around 11,500 years ago, Bruce Bower reported in “Dogs may have helped ancient Middle Easterners hunt small game” (SN: 2/16/19, p. 13).

Reader Eric Hobday took issue with the researchers’ conclusion that dogs assisted with hunting. “I will accept as fact that the bones in Shubayqa show signs of having passed through a dog’s digestive system. However, this in no way indicates that the dog in Shubayqa was any more involved in hunting the animal than my dog was,” Hobday wrote. He suggested that the dogs could have been feral and scavenged villagers’ leftovers. “No evidence of domestication was presented, yet the article says the findings offer new insights into domestication,” Hobday wrote. “Really?”

By comparing bones of modern Afghan hounds, greyhounds, gray wolves and golden jackals, researchers have determined that the Shubayqa 6 bones likely came from domesticated dogs, Bower says. “As pointed out in the story, the presence of numerous dogs at the site fits with observations of modern foragers who use dogs to locate small prey during hunts,” he says. “Reconstructions of ancient behavior are always provisional.”
Soil science
High demand for sparkling wine may be depleting 400 million kilograms of soil every year from northeastern Italy’s vineyards, Cassie Martin reported in “Prosecco production takes a toll on northeast Italy’s environment” (SN: 2/16/19, p. 5).

“The best wine grows in poor soil conditions,” reader Jonathan Quint wrote. “Is erosion even a concern for a vineyard?”

Soil erosion isn’t necessarily a bad thing. It can help generate new soils to keep an ecosystem healthy. But such a high rate of soil erosion in Italy is a big concern, says Jesús Rodrigo Comino, a geographer at the University of Málaga’s Institute of Geomorphology and Soils in Spain. The current rate is unsustainable and could actually harm vineyards there. A few simple changes, like leaving grass between rows of vines as well as planting hedges around vineyards and vegetation along rivers and streams, might help prosecco vineyards reduce their soil loss, scientists suggest.

On the rise
Deaths involving a type of antianxiety medication rose 830 percent from 1999 to 2017 in U.S. women ages 30 to 64, Aimee Cunningham reported in “Overdose deaths tied to antianxiety drugs like Xanax continue to rise” (SN: 2/16/19, p. 12).

Reader Dan Furtado asked if benzodiazepines alone cause overdose deaths. He thought that the drugs, such as Xanax and Valium, could cause an overdose only if a person had additional medical issues or combined the drugs with opioids or similar substances.

“An overdose of benzodiazepines alone can cause death,” Cunningham says. “The drugs depress the central nervous system, so a person who overdoses can stop breathing. But overdose deaths are more likely to happen when benzodiazepines are taken with opioids or alcohol,” she says.

Antarctica’s iceberg graveyard could reveal the ice sheet’s future

Just beyond the tip of the Antarctic Peninsula lies an iceberg graveyard.

There, in the Scotia Sea, many of the icebergs escaping from Antarctica begin to melt, depositing sediment from the continent that had been trapped in the ice onto the seafloor. Now, a team of researchers has embarked on a two-month expedition to excavate the deposited debris, hoping to discover secrets from the southernmost continent’s climatic past.

That hitchhiking sediment, the researchers say, can help piece together how Antarctica’s vast ice sheet has waxed and waned over millennia. And knowing how much the ice melted in some of those warmest periods, such as the Pliocene Epoch about 3 million years ago, may provide clues to the ice sheet’s future. That includes how quickly the ice may melt in today’s warming world and by how much, says paleoclimatologist Michael Weber of the University of Bonn in Germany.
Weber and Maureen Raymo, a paleoclimatologist at Lamont-Doherty Earth Observatory in Palisades, N.Y., are leading the expedition, which set sail on March 25.

“By looking at material carried by icebergs that calved off of the continent, we should be able to infer which sectors of the ice sheet were most unstable in the past,” Raymo says. “We can correlate the age and mineralogy of the ice-rafted debris to the bedrock in the section of Antarctica from which the bergs originated.”
Icebergs breaking off from the edges of Antarctica’s ice sheet tend to stay close to the continent, floating counterclockwise around the continent. But when the bergs reach the Weddell Sea, on the eastern side of the peninsula, they are shunted northward through a region known as Iceberg Alley toward warmer waters in the Scotia Sea.

Because so many icebergs from all around the continent converge in one region, it is the ideal place to collect sediment cores and take stock of the debris that the bergs have dropped over millions of years.

“That area in the Scotia Sea is so exciting, because it’s a focus point between South America and the Antarctic Peninsula where the currents flow through, and there are a lot of icebergs,” says Gerhard Kuhn, a marine geologist at the Alfred Wegener Institute in Bremerhaven, Germany. “You get a picture of more or less [all of] Antarctica in that area,” says Kuhn, who has studied the region but is not aboard the current cruise.
The expedition, known as leg 382 of the International Ocean Discovery Program, plans to drill at six different sites in the Scotia Sea. At three sites, the team plans to penetrate about 600 meters into the seafloor. “That would likely bring us back to the mid-Miocene, which could translate into 12 million to 18 million years back in time,” Weber says.

At another site, the team plans to drill even deeper, 900 meters, to go further back in time, in hopes of finding sediments that date to the opening of the Drake Passage about 41 million years ago. That passage, a body of water that now lies between South America and Antarctica, opened a link between the Atlantic and Pacific oceans and may have played a role in building up Antarctica’s ice sheets at different times in its history.

A graveyard turned crystal ball
How much a melting Antarctica might have contributed to global sea-level rise following the last great ice age, which ended about 19,000 years ago, has been a subject of debate. Seas rose by about 130 meters from 19,000 to 8,000 years ago, Weber says, and much of the melting happened in the northern hemisphere.

But Antarctica may have played a larger role than once thought. In a study published in Nature in 2014, Kuhn, Weber and other colleagues reported that ice-rafted debris from that time period, as recorded in relatively short sediment cores from Iceberg Alley, often occurred in large pulses lasting a few centuries to millennia. Those data suggested that the southernmost continent was shedding lots of bergs much more quickly during those times than once thought.

Now, the researchers want to see even further into the past, to understand how quickly Antarctica’s ice sheet might have melted during even warmer periods, and how much it may have contributed to episodes of past sea-level rise.

The new drilling expedition targets several periods when the climate is thought to have warmed dramatically. One is a warm period in the middle Pliocene about 3.3 million to 3 million years ago, when average global temperatures were 2 to 3 degrees warmer than today; another is the ending of an older ice age about 130,000 years ago, when sea levels rose by about 5 to 9 meters.

Such periods may serve as analogs to the continent’s future behavior due to anthropogenic global warming. Currently, global average temperatures on Earth are projected to increase by between about 1.5 degrees and 4 degrees Celsius relative to preindustrial times, depending on greenhouse gas emissions to the atmosphere over the next few decades (SN: 10/22/18, p. 18).

“The existing [ice core] record from Iceberg Alley taught us Antarctica lost ice through a threshold reaction,” Weber says. That means that when the continent reached a certain transition point, there was sudden and massive ice loss rather than just a slow, gradual melt.

“We have rather firm evidence that this threshold is passed once the ice sheet loses contact with the underlying ocean floor,” he says, adding that at that point, the shedding of ice becomes self-sustaining, and can go on for centuries. “With mounting evidence of recent ice-mass loss in many sectors of West Antarctica of a similar fashion, we need to be concerned that a new ice-mass loss event is already underway, and there is no stopping it.”

The first picture of a black hole opens a new era of astrophysics

This is what a black hole looks like.

A world-spanning network of telescopes called the Event Horizon Telescope zoomed in on the supermassive monster in the galaxy M87 to create this first-ever picture of a black hole.

“We have seen what we thought was unseeable. We have seen and taken a picture of a black hole,” Sheperd Doeleman, EHT Director and astrophysicist at the Harvard-Smithsonian Center for Astrophysics in Cambridge, Mass., said April 10 in Washington, D.C., at one of seven concurrent news conferences. The results were also published in six papers in the Astrophysical Journal Letters.

“We’ve been studying black holes so long, sometimes it’s easy to forget that none of us have actually seen one,” France Córdova, director of the National Science Foundation, said in the Washington, D.C., news conference. Seeing one “is a Herculean task,” she said.
That’s because black holes are notoriously hard to see. Their gravity is so extreme that nothing, not even light, can escape across the boundary at a black hole’s edge, known as the event horizon. But some black holes, especially supermassive ones dwelling in galaxies’ centers, stand out by voraciously accreting bright disks of gas and other material. The EHT image reveals the shadow of M87’s black hole on its accretion disk. Appearing as a fuzzy, asymmetrical ring, it unveils for the first time a dark abyss of one of the universe’s most mysterious objects.

“It’s been such a buildup,” Doeleman said. “It was just astonishment and wonder… to know that you’ve uncovered a part of the universe that was off limits to us.”

The much-anticipated big reveal of the image “lives up to the hype, that’s for sure,” says Yale University astrophysicist Priyamvada Natarajan, who is not on the EHT team. “It really brings home how fortunate we are as a species at this particular time, with the capacity of the human mind to comprehend the universe, to have built all the science and technology to make it happen.” (SN Online: 4/10/19)

The image aligns with expectations of what a black hole should look like based on Einstein’s general theory of relativity, which predicts how spacetime is warped by the extreme mass of a black hole. The picture is “one more strong piece of evidence supporting the existence of black holes. And that, of course, helps verify general relativity,” says physicist Clifford Will of the University of Florida in Gainesville who is not on the EHT team. “Being able to actually see this shadow and to detect it is a tremendous first step.”

Earlier studies have tested general relativity by looking at the motions of stars (SN: 8/18/18, p. 12) or gas clouds (SN: 11/24/18, p. 16) near a black hole, but never at its edge. “It’s as good as it gets,” Will says. Tiptoe any closer and you’d be inside the black hole — unable to report back on the results of any experiments.
“Black hole environments are a likely place where general relativity would break down,” says EHT team member Feryal Özel, an astrophysicist at the University of Arizona in Tucson. So testing general relativity in such extreme conditions could reveal deviations from Einstein’s predictions.

Just because this first image upholds general relativity “doesn’t mean general relativity is completely fine,” she says. Many physicists think that general relativity won’t be the last word on gravity because it’s incompatible with another essential physics theory, quantum mechanics, which describes physics on very small scales.
The image also provides a new measurement of the black hole’s size and heft. “Our mass determination by just directly looking at the shadow has helped resolve a longstanding controversy,” Sera Markoff, a theoretical astrophysicist at the University of Amsterdam, said in the Washington, D.C., news conference. Estimates made using different techniques have ranged between 3.5 billion and 7.22 billion times the mass of the sun. But the new EHT measurements show that its mass is about 6.5 billion solar masses.

The team has also determined the behemoth’s size — its diameter stretches 38 billion kilometers — and that the black hole spins clockwise. “M87 is a monster even by supermassive black hole standards,” Markoff said.

EHT trained its sights on both M87’s black hole and Sagittarius A, the supermassive black hole at the center of the Milky Way. But, it turns out, it was easier to image M87’s monster. That black hole is 55 million light-years from Earth in the constellation Virgo, about 2,000 times as far as Sgr A. But it’s also about 1,000 times as massive as the Milky Way’s giant, which weighs the equivalent of roughly 4 million suns. That extra heft nearly balances out M87’s distance. “The size in the sky is pretty darn similar,” says EHT team member Feryal Özel.
Due to its gravitational oomph, gases swirling around M87’s black hole move and vary in brightness more slowly than they do around the Milky Way’s. “During a single observation, Sgr A* doesn’t sit still, whereas M87 does,” says Özel, an astrophysicist at the University of Arizona in Tucson. “Just based on this ‘Does the black hole sit still and pose for me?’ point of view, we knew M87 would cooperate more.”

After more data analysis, the team hopes to solve some long-standing mysteries about black holes, such as how M87’s behemoth spews a bright jet of charged particles thousands of light-years into space.

This first image is like the “shot heard round the world” that kicked off the American Revolutionary War, says Harvard University astrophysicist Avi Loeb who isn’t on the EHT team. “It’s very significant; it gives a glimpse of what the future might hold, but it doesn’t give us all the information that we want.”
Hopes are still high for a much-anticipated glimpse of Sgr A*. The EHT team was able to collect some data on the Milky Way’s behemoth and are continuing to analyze that data, in the hopes of adding its image to the new black hole portrait gallery.

Since the appearance of that black hole changes so quickly, the team is having to develop new techniques to analyze the data. “We’re very excited to work on Sgr A*,” Daniel Marrone, an astrophysicist at the University of Arizona in Tucson, said in the Washington, D.C., news conference. “We’re doing that shortly. We’re not promising anything but we hope to get that very soon.”

Studying such different environments could reveal more details of how black holes behave, Loeb says. “The Milky Way is a very different galaxy from M87.”
The next look at the M87 and Milky Way behemoths will have to wait.

Scientists got a lucky stretch of good weather at all eight sites that made up the Event Horizon Telescope in 2017. Then bad weather in 2018 and technical difficulties, which cancelled the 2019 observing run, stymied the team.

The good news is that by 2020, there will be more observatories to work with. The Greenland Telescope joined the consortium in 2018, and the Kitt Peak National Observatory outside Tucson, Ariz., and the NOrthern Extended Millimeter Array (NOEMA) in the French Alps will join EHT in 2020.

Adding more telescopes could allow the team to extend the image, to better capture the jets that spew from the black hole. The researchers also plan to make observations using light of slightly higher frequency, which can further sharpen the image. And even bigger plans are on the horizon: “World domination is not enough for us; we also want to go to space,” Doeleman said.

These extra eyes may be just what’s needed to bring black holes into even greater focus.

All you need to know about the history of black holes

Black holes have been beguiling from the very beginning.

Hinted at as early as the 1780s and predicted by Einstein’s general theory of relativity, they didn’t get the name we know today until the 1960s. Bizarre beasts that squash gobs of matter into infinitely dense abysses, black holes were once thought to be merely a mathematical curiosity.

But astronomers tallied up evidence for black holes’ existence bit by bit, puzzling over where these behemoths live, how they gulp down matter and what their existence means for other physics theories.

For more than a decade, a team of researchers has been engrossed in an ambitious effort to snap a picture of a black hole for the very first time. And now they’ve done it. What better time to think back to black holes’ origins and the journey so far?

Wildfires in boreal forests released a record amount of CO2 in 2021

WASHINGTON — In 2021, wildfires pillaged the world’s carbon-rich snow forests.

That year, burning boreal forests released 1.76 billion metric tons of carbon dioxide, researchers reported March 2 in a news conference at the annual meeting of the American Association for the Advancement of Science.

That’s a new record for the region, which stores about one-third of the world’s land-based carbon. “It’s also roughly double the emissions in that year from aviation,” said earth system scientist Steven Davis of the University of California, Irvine. The trend, if it continues, threatens to make fighting climate change even more difficult.
Boreal forests are part of the taiga, a vast region that necklaces the Earth just south of the Arctic Circle. Blazes in tropical forests like the Amazon tend to garner more attention for their potential to contribute large amounts of climate-warming gases to the atmosphere (SN: 9/28/17). But scientists estimate that on a per area basis, boreal forests store about twice as much carbon in their trees and soils as tropical forests.

Climate change is causing the taiga to warm about twice as fast as the global average. And wildfires are growing more widespread in the region, releasing more of the trapped carbon, which in turn can worsen climate change (SN: 5/19/21).

Davis and his colleagues analyzed satellite data on carbon emissions from boreal regions from 2000 to 2021. In 2021, emissions from boreal wildfires made up a whopping 23 percent of all the CO2 emitted by wildfires around the world, the researchers report in the March 3 Science. In contrast, CO2 emissions during an average year from 2000 to 2021 were about 10 percent.

The record-breaking emissions coincided with widespread heat waves and droughts in Siberia and northern Canada, probably fueled by human-caused climate change.

There’s no data yet to show if 2022 saw a similar surge in emissions. But, Davis said, “there’s not actually that much evidence that this record will stand for long.”

Many Antarctic glaciers are hemorrhaging ice. This one is healing its cracks

Even as some parts of West Antarctica rapidly melt, raising sea level, large swaths of the ice remain stable for the time being. Scientists have now explored one of those stable spots — an isolated nook where the ocean meets the ice. There, the team found the underside of the ice sculpted into strange grooves, ripples and globes.
This environment is “really at the edge” between melting and freezing, says planetary scientist Justin Lawrence. The delicate balance between these two processes is shaping the ice into those strange textures — similar to the way that minerals dissolve and recrystallize to form the beautiful shapes inside limestone caverns.
The result, at Kamb Ice Stream, is that massive cracks in the underside of the ice appear to be freezing back together as the beach ball–sized globes fill in the crevasses from above, Lawrence and colleagues report March 2 in Nature Geoscience.
This refreezing differs from what’s happening at Antarctica’s Thwaites Glacier. There, scientists recently reported that these cracks, known as basal crevasses, are instead sites of rapid melting (SN: 2/15/23).
Understanding what is happening at Kamb will help scientists predict how large parts of the Antarctic coastline that are not currently vulnerable might respond as the world continues to warm due to human-caused climate change. Here’s what’s different about Kamb.
Supercold water underlies the ice at Kamb, slowing melting
In December 2019, two teams of researchers from New Zealand and the United States visited the Kamb Ice Stream — a type of glacier that consists of a channel of faster-moving ice surrounded by slower ice.
Kamb, like much of the rest of the West Antarctic Ice Sheet, rests on a bed that is hundreds of meters below sea level. The New Zealand team used hot water to melt a narrow hole through the ice, just downstream of the “grounding zone,” where the glacier lifts off its muddy bed and floats on the ocean.
The U.S. team then lowered a remote-operated vehicle called Icefin down through 580 meters of ice and into the seawater below. The researchers piloted Icefin as far as a kilometer from the borehole, navigating by video transmitted up through a cable. At the time of the expedition, the team operating Icefin was affiliated with Georgia Tech in Atlanta, but has since moved to Cornell University, except for Lawrence. He now works for Honeybee Robotics, a private company in Altadena, Calif.
Icefin found that much of the seawater beneath Kamb is about 0.3 degrees Celsius above freezing. But directly below the ice sits a colder layer, a mixture of seawater and glacial meltwater just 0.02 to 0.08 degrees C above freezing. Based on these measurements, Lawrence and his colleagues estimate that the exposed underside of Kamb is melting about 26 centimeters per year.
In contrast, recent measurements at the increasingly unstable Thwaites Glacier, about 1,400 kilometers to the northeast, found the seawater at the glacier’s grounding zone 1 to 2 degrees C warmer than at Kamb — and the ice melting 5 to 40 meters per year.
The new finding at Kamb makes sense, says New Zealand team member Christina Hulbe, of the University of Otago, because the seabed at Kamb is relatively shallow. So it is not exposed to the deep, warm ocean currents that are hitting Thwaites.
Much of Antarctica is fringed by cold ocean environments similar to Kamb, she says. “So just understanding that system is important.”
Greenish globs of refrozen ice fill cracks at Kamb
As Icefin glided along, its sonars detected massive basal crevasses up to 55 meters across in the ice above. These cracks probably formed as the floating part of the glacier, the ice shelf, flexes up and down with ocean tides.
Lawrence and his colleagues guided the ROV into one of these cracks, and found its white, icy sidewalls carved into narrow vertical grooves. Icefin ascended 40 meters up, until the grooves suddenly vanished — replaced by a jumble of ice globes, which seemed to fill the upper half of the crevasse.
The globes were greenish — a hue often seen in winter ice that forms on the surface of the ocean. This color makes Lawrence and his colleagues think that the globes form from the ultracold mixture of seawater and meltwater that circulates up into a crack and refreezes, gradually filling in the crack, from the top down, over many decades. They think that this is happening in all of the crevasses they observed. “These crevasses are effectively healing themselves,” he says.
This refreezing process might also explain the strange vertical grooves in the walls of the crevasse, Lawrence speculates. As the water freezes, salt is pushed out of the newly forming ice crystals, creating tiny pockets of highly concentrated brine. That dense brine streams down the walls, melting grooves into the ice — similar to the way that salt causes ice to melt when it’s sprinkled onto a sidewalk in the wintertime.
To observe the crevasses refreezing under Kamb “is pretty exceptional,” says Ginny Catania, a glaciologist at the University of Texas at Austin who was not part of the project. Those cracks “can propagate all the way to the surface and cause calving” of icebergs, she says, which can shrink the ice shelf if it happens too quickly, destabilizing the glacier and raising sea level.
But if the crevasses can actually heal, this could make these ice shelves more resistant to calving — and more stable — than scientists realized, at least as long as the ice continues to be bathed in cold water on the underside.
A string of instruments installed in the hole continued to measure the temperature and salinity of the water beneath the ice — transmitting that data up a cable to the ice’s surface, and back home via satellite until the batteries ran out two years later. Those data show that conditions down below remained cool and comfortable for Kamb.

The fastest claw in the sea belongs to young snapping shrimp

Full-grown snapping shrimp were already known to have some of the fastest claws under the waves. But it turns out they’re nothing compared with their kids.

Juvenile snapping shrimp produce the highest known underwater accelerations of any reusable body part, researchers report February 28 in the Journal of Experimental Biology. While the claws’ top speed isn’t terribly impressive, they go from zero to full throttle in record time.

To deter predators or competitors, snapping shrimp create shock waves with their powerful claws. The shrimp store energy in the flexing exoskeleton of their claw as it opens, latching it in place much like a bow-and-arrow mechanism, says Jacob Harrison, a biologist at Georgia Tech in Atlanta.
Firing the claw and releasing this elastic energy produces a speeding jet of water. Bubbles form behind it and promptly implode, liberating a huge amount of energy, momentarily flashing as hot as the sun and creating a deafening crack (SN: 10/3/01).

But it was unclear how early in their lives the shrimp could use this weaponry. “We knew that the snapping shrimp did this really impressive behavior,” Harrison says. “But we really didn’t know anything about how this mechanism developed.”

While a grad student at Duke University, Harrison and his adviser, biomechanist Sheila Patek, reared bigclaw snapping shrimp (Alpheus heterochaelis) from eggs in the laboratory. At 1 month old, the tiny shrimp — less than a centimeter long — began firing their claws when disturbed. The researchers took high-speed video footage of these snaps and calculated their speed.

The wee shrimp could create the collapsing bubbles just like adults. Despite being a tenth the adults’ size or smaller, the juveniles’ claws accelerated 20 times as fast when firing. This acceleration — about 600 kilometers per second per second — is on “the same order of magnitude as a 9-millimeter bullet leaving a gun,” Harrison says.
Dracula ants (Mystrium camillae) and some termites produce more explosive bites but aren’t pushing against water. The stinging cells of jellyfish launch their venomous harpoons about 100 times as fast, but their firing mechanism is inherently single use. Snapping shrimp, on the other hand, can fire their claws again and again.
The juveniles’ firing and bubble creation weren’t very reliable at the smallest sizes, but the shrimp routinely tried snapping anyway. The team wonders if the young shrimp could be practicing and training the necessary musculature.

If so, that training might ultimately be crucial to the claw’s function, says Kate Feller, a visual ecologist at Union College in Schenectady, N.Y., who studies similarly ultrafast mantis shrimp and was not involved in the new study. “If you were to somehow manipulate the claws so that they couldn’t properly close and they couldn’t snap,” she wonders, “would that affect their ability to develop these mechanisms?”

Understanding the storage of elastic energy in biological materials and how it flows through them is “tricky,” Harrison says. Figuring out how such tiny claws store so much energy without fracturing may help researchers illuminate this superpower.

Here’s how lemon juice may fend off kidney stones

A surprise ingredient may explain how lemon juice puts the squeeze on kidney stones.

Lemons contain nanoparticles that, when fed to rats, block stone formation, scientists report in the Feb. 22 Nano Letters. If the tiny sacs do the same for humans, the nanoparticles might one day offer a way to prevent kidney stones in people, says pharmaceutical scientist Hongzhi Qiao of Nanjing University of Chinese Medicine.

Lemon juice is a well-known home remedy for kidney stones, which form when minerals crystalize and clump up inside the kidney (SN: 9/21/18). These rocky lumps can knock around in the urinary tract, slicing and dicing tissues as they eventually pass out of the body (SN: 10/31/16). “It’s so, so, so painful,” says Jingyin Yan, a nephrologist at Baylor College of Medicine in Houston who was not part of the new study. Patients may feel sharp pain in their back, side or lower abdomen when they pass a stone, she says. “People describe it as worse than delivering a baby.”
Though some medications can help treat kidney stones, many people end up needing surgery to remove them, says Thomas Chi, a urologist at the University of California, San Francisco, also not part of the study. People often imagine kidney stones as tiny pebbles, but sometimes they bulk up like boulders, he adds. “I’ve taken out stones the size of your fist.”

That’s why prevention is key. Scientists already knew that citric acid, which gives lemons their sour power, may do the trick by binding to the minerals that make up stones. But drinking mouth-puckering lemon juice is not so comfortable for patients, Qiao says.

A 2022 clinical trial found that kidney stone patients had trouble downing 120 milliliters — about a half cup — of lemon juice per day. Swilling loads of lemonade can cause dental problems, too. Chi has had patients drink so much that the acidic liquid ate away at their teeth.

So Qiao and colleagues looked for other, more palatable lemon-derived ingredients that might help prevent kidney stones. Inside edible and medicinal plants like ginseng, grapefruit and dandelion, his team has found extracellular vesicle-like nanoparticles, tiny sacs stuffed with molecules including fat, protein and DNA.
These nanoparticles exist in lemon juice, too­­ — and the team fed them to rats that had also ingested a substance that promotes kidney stone growth. The zesty particles slowed stone formation, Qiao and colleagues found. The finding suggests these particles curb development of calcium oxalate crystals, the most common culprit of kidney stones. The particles can also soften the stones and make them less sticky, the team showed.

The new work challenges the conventional wisdom on how lemon juice works to combat kidney stones, Chi says. Using lemon nanoparticles to treat people is still a long way off, but the team’s results hold promise, he says. “The faster you can bring a finding like this towards a human clinical trial, the better.”

Ancestral humans had more DNA

A new atlas of human genetic diversity reveals what human ancestors’ DNA may have looked like before people migrated out of Africa.

Ancestral humans carried 40.7 million more DNA base pairs than people do today, researchers report online August 6 in Science. That’s enough DNA to build a small chromosome, says study coauthor Evan Eichler, an evolutionary geneticist at the University of Washington in Seattle.

Human ancestors in Africa jettisoned 15.8 million of those DNA base pairs — information-carrying building blocks of DNA often referred to by the letters A, T, G and C — before dispersing around the globe, the researchers discovered. As people left Africa and spread to other continents, they dropped more chunks of DNA. Eichler and colleagues have followed these genetic bread crumbs to map relationships among 125 human groups worldwide.
People didn’t just lose DNA. They also gained some. Compared with chimpanzees and orangutans, people have 728 extra pieces of DNA created when portions of the human genetic instruction book, the genome, were copied. Everyone has at least three copies of those duplicated bits, although the exact number varies from person to person.

Previous maps of human genetic diversity have usually not marked the yawning chasms left by deletions or the new territory created by duplications. Most diversity maps have focused on single DNA base pair changes, often called single nucleotide polymorphisms, or SNPs. But all the SNPs together comprise only 1.1 percent of the genome. Duplications and deletions, collectively known as copy number variants, have shaped more than 7 percent of the human genome.

Story continues below infographic
Because duplications and deletions involve larger swaths of DNA than SNPs do, their influence on human evolution may also be bigger. Both duplications and deletions have been implicated in shaping human characteristics, such as bigger brains (SN: 3/21/15, p. 16; SN: 4/9/11, p. 15).

But researchers “can’t answer the question yet of whether what makes us human is in what was lost or what was duplicated,” says David Liberles, a computational evolutionary biologist at Temple University in Philadelphia.

Eichler’s choice is clear. “Duplications rock,” he says. “They affect more base pairs in the human genome than any other type of variation.” Duplications span 4.4 percent of the genome, while deletions represent 2.77 percent. And duplications tend to involve genes, while deletions often fall in spaces between genes, the researchers found.

His team flagged many duplications as possible medical and evolutionary points of interest. For instance, some groups of people have up to six copies of CLPS genes, which encode pancreatic enzymes that may help reduce blood sugar levels. Some African groups carry duplications of genes that may protect against sleeping sickness caused by trypanosome parasites.

Another attraction is a very large duplication of about 225,000 base pairs that Papua New Guineans inherited from Denisovans, an extinct group of hominids related to Neandertals. The colossal hunk of DNA contains two microRNA genes. MicroRNAs are small molecules that help regulate protein production. Eichler and colleagues calculate that the original duplication happened about 440,000 years ago in Denisovans. It was passed to Papuans and some other Melanesians about 40,000 years ago when their ancestors interbred with Denisovans. Now, about 80 percent of Papuans carry the duplication. Eichler speculates that the duplication may have given Papuan ancestors some evolutionary advantage, although what that advantage might be isn’t known.

While the researchers make a compelling case that duplications and deletions may play an important role in evolution, the team has provided little evidence that copy number variants really determine trait differences between groups, says Edward Hollox, a human geneticist at the University of Leicester in England. “It’s almost a paper saying, ‘Look, isn’t this interesting?’ But why it’s interesting they haven’t quite gotten to the bottom of.” Still, Hollox says the map will point other researchers to parts of the genome where evolution may have left its mark.

Claim of memory transfer made 50 years ago

Memory Transfer Seen — Experiments with rats, showing how chemicals from one rat brain influence the memory of an untrained animal, indicate that tinkering with the brain of humans is also possible.

In the rat tests, brain material from an animal trained to go for food either at a light flash or at a sound signal was injected into an untrained rat. The injected animals then “remembered” whether light or sound meant food.
Update:
After this report, scientists from eight labs attempted to repeat the memory transplants. They failed, as they reported in Science in 1966.

Science fiction authors and futurists often predict that a person’s memories might be transferred to another person or a computer, but the idea is likely to remain speculation, says neuroscientist Eric Kandel, who won a Nobel Prize in 2000 for his work on memory. Brain wiring is too intricate and complicated to be exactly replicated, and scientists are still learning about how memories are made, stored and retrieved.