SAN ANTONIO — A roughly 3,000-year-old cemetery on Israel’s coast is providing an unprecedented look at burial practices of the Philistines, a mysterious population known from the Old Testament for having battled the Israelites.

Work at the Ashkelon cemetery from 2013 to 2016 has uncovered remains of at least 227 individuals, ranging from infants to older adults. Only a small section of the cemetery has been explored. Archaeologist and excavation director Adam Aja of the Harvard Semitic Museum estimates that approximately 1,200 people were interred there over a span of about 100 years.
“For the first time, we have found a formal Philistine cemetery,” Aja said November 18 at the annual meeting of the American Schools of Oriental Research. Aja and his colleagues first announced having found the Philistine graveyard on July 10. He was among several researchers to present their latest findings about the cemetery at the meeting.

Despite the new discoveries, the geographic origins of the Philistines remain unknown, Aja said. It’s also unclear how early Philistines reached the Middle East or how much their culture changed by the time they started burying their dead at Ashkelon.

Philistine burial practices have been discussed and debated for about a century. Other ancient Philistine sites in Israel, also identified in ancient texts, have yielded individual graves and small-scale burial grounds.

At Ashkelon, the dead were interred in several ways. Most individuals were placed in shallow pits, often with pairs of jugs or storage containers near the bodies. Some pits contained a person’s remains that had been buried on top of one or more previously interred bodies. Bronze earrings, bracelets, rings and other jewelry adorn most skeletons of children and women. Several pit graves of male skeletons include ornamental beads or engraved stones.

One grave holds a set of iron arrows near a man’s hip. A quiver probably once held the arrows at the man’s side, Aja suggested.
Researchers also uncovered ashes and bone fragments from six human cremations in sealed jars placed in pit graves.

At least eight stone burial chambers capped with stone slabs were also found. The largest chamber held skeletons of 23 individuals. These burial chambers were aligned in three rows that ran parallel to the coast, Aja said.

Tapered storage jars found in pit graves and burial chambers were influenced by pottery of the Canaanites, a nearby population along the Mediterranean coast, said team member Janling Fu of Harvard University.

Fu suspects the excavation is located at the cemetery’s edge. Considerable space between some burials suggests denser clusters of grave sites lie nearby, he proposed, raising the prospect of learning much more about how the Philistines treated their dead.

Although the excavation is in its early stages, it’s clear that Philistines buried at Ashkelon show signs of physiological stress, reported bioarchaeologist and team member Sherry Fox of Eastern Michigan University in Ypsilanti. Many individuals’ teeth have signs of growth interruptions caused by fever, malnutrition or a range of possible biological disorders, she said.

Relatively short average heights for people buried at Ashkelon — about 5 feet, 1 inch for men and 4 feet, 10 inches for women — also fit a scenario of biological stress, Fox said. Short stature and minimal height differences between men and women occur with population-wide stresses such as malnutrition, she said.

The Philistines were a famously combative crowd. Archaeologist Eric Meyers of Duke University, who was not a member of the Ashkelon team, wondered if at least some of those buried at Ashkelon had been killed in battles or fights. But no head injuries or other skeletal signs of violent encounters appeared among the dead at Ashkelon, Fox said. Neither did any skeletons contain evidence of tumors or cancers.

If DNA can be extracted from the Ashkelon skeletons, scientists may get a glimpse of where the Philistines originally came from. Evolutionary geneticist Johannes Krause of the Max Planck Institute for the Science of Human History in Jena, Germany, is currently directing efforts to retrieve genetic sequences from the Ashkelon bones.

“Our work has only just begun,” Aja said.

Our grasp of food allergy science is as jumbled as a can of mixed nuts. While there are tantalizing clues on how food allergies emerge and might be prevented, misconceptions are plentiful and broad conclusions are lacking, concludes a new report by the National Academies of Sciences, Engineering and Medicine.

As a result, both the general public and medical community are confused and ill-informed about food allergies and what to do about them. Most prevention strategies and many tests used to diagnose a food allergy aren’t supported by scientific evidence and should be abandoned, the 562-page report concludes.
“We are much more in the dark than we thought,” says Virginia Stallings, a coeditor of the new report, released November 30.

While solid data are hard to come by, the report notes, estimates suggest that 12 million to 15 million Americans suffer from food allergies. Common culprits include peanuts, milk, eggs, fish, shellfish, sesame, wheat and soy.

Food allergies should be distinguished from food intolerances; the two are often confused by the public and practitioners, says Stallings, a pediatrician and research director of the nutrition center at the Children’s Hospital of Philadelphia. Strictly defined food allergies, the primary focus of the report, arise from a specific immune response to even a small amount of the allergen; they produce effects such as hives, swelling, vomiting, diarrhea and, most crucially, anaphylaxis, a severe, potentially deadly allergic reaction. These effects reliably occur within two hours after every time a person ingests that food. Allergic reactions that fall outside this strict definition and food-related intolerances, such as a gastrointestinal distress after ingesting lactose, are a legitimate public health concern. But the mechanisms behind them are probably very different than the more strictly defined food allergies, as are the outcomes, says Stallings.

Anyone suspecting a food allergy should see a specialist. If medical history and preliminary results hint at problems, then the gold standard diagnostic test should be applied: the oral food challenge. This test exposes an individual to small amounts of the potentially offending food while under supervision. Doctors and others in health care should abandon many unproven tests, such as ones that analyze gastric juices or measure skin’s electrical resistance, the report concludes.

Regarding prevention, research has borne a little fruit: The authors recommend that parents should give infants foods that contain potential allergens. This recommendation is largely based on peanut allergy research suggesting early exposure is better than late (SN: 3/21/2015, p. 15). There’s little to no evidence supporting virtually all other behaviors thought to prevent food allergies, such as taking vitamin D supplements, or women avoiding allergens while pregnant or breastfeeding.
While additional rigorous long-term studies are needed to better understand why food allergies arise, the report addresses many issues that society can confront in the meantime. Industry needs to develop a low-dose (0.075 milligrams) epinephrine injector to treat infants who experience food allergy anaphylaxis; the U.S. Food and Drug Administration, Department of Agriculture and the food manufacturing industry need to revamp food labeling so it reflects allergy risks; and relevant agencies should establish consistent guidelines for schools and airplanes that include first-aid training and on-site epinephrine supplies.

“This report is mammoth and very impressive,” says Anita Kozyrskyj, whose research focuses on the infant gut microbiome. Kozyrskyj, of the University of Alberta in Canada, presented research to the reports’ authors while they were gathering evidence. She says the report identifies issues that can help guide the research community. But its real value is in the recommendations for parents, schools, caregivers and health care providers who are dealing with food allergies in the here and now.

The first normally solitary spider to win Dad of the Year sets up housekeeping in a web above his offspring and often ends up as their sole defender and single parent.

Moms handle most parental care known in spiders, says Rafael Rios Moura at the Federal University of Uberlândia in Brazil. But either or both parents care for egg sacs and spiderlings in the small Manogea porracea species he and colleagues studied in a eucalyptus plantation. The dad builds a dome-shaped web above the mom’s web, and either parent will fight hungry invaders looking for baby-spider lunch. In webs with no parents, only about four spiderlings survived per egg sac. But with dad, mom or both on duty, survival more than doubled, the researchers report in the January 2017 Animal Behaviour.
“To the best of my knowledge, there really aren’t other examples where male spiders step up to care for young or eggs,” says Linda Rayor of Cornell University, who has studied spider maternal care. In a group-living Stegodyphus species, some of the males in a communal web will attack intruders, but Manogea dads do much more. They switch from solitary life to a dad-web upstairs, brush rainwater off egg sacs and share defense, sometimes at the cost of their own lives.
Many male web-building spiders stop feeding as adults because they’re out searching for mates instead of catching food with their web, Moura says. Manogea males, however, stick with a female they mated with and build a new food-catching web. Now Moura would like to know whether such commitment makes males unusually choosy about females, he says.

To predators, females “must be very delicious,” Moura says. In the wild he found that many females disappeared, probably eaten, by the end of the breeding season, leaving dads as the sole protector for 68 percent of the egg sacs.

That high female mortality could have been important for evolution of the dads’ care-taking, says behavioral ecologist Eric Yip of Penn State. Just why this species has such high female mortality puzzles him, though. Females, geared up for egg-laying, have rich nutrient stores. Yet, he says, “that’s generally true for all spiders — that females are going to be more nutritious and males are going to be mostly legs.”

A seahorse’s genetic instruction book is giving biologists a few insights into the creature’s odd physical features and rare parenting style.

Researchers decoded a male tiger tail seahorse’s (Hippocampus comes) genome and compared it to the genomes of other seahorses and ray-finned fishes. The analysis revealed a bevy of missing genes and other genetic elements responsible for enamel and fin formation. The absence of these genes may explain their tubelike snouts, small toothless mouths, armored bodies and flexible square tails, the team reports online December 14 in Nature.

Although H. comes may be short a few genes, the seahorse has a surplus of other genes important for male pregnancy — a trait unique to seahorses, sea dragons and pipefish. These genetic differences suggest the tiger tail seahorse has evolved more quickly than its relatives, the researchers conclude.

Famous footprints of nearly 3.7-million-year-old hominids, found in 1976 at Tanzania’s Laetoli site, now have sizable new neighbors.

While excavating small pits in 2015 to evaluate the impact of a proposed field museum at Laetoli, researchers uncovered comparably ancient hominid footprints about 150 meters from the original discoveries. The new finds reveal a vast range of body sizes for ancient members of the human evolutionary family, reports an international team led by archaeologists Fidelis Masao and Elgidius Ichumbaki, both of the University of Dar es Salaam in Tanzania.
A description of the new Laetoli footprints appears online December 14 in eLife.

Scientists exposed 14 hominid footprints, made by two individuals as they walked across wet volcanic ash. More than 500 footprints of ancient horses, rhinos, birds and other animals dotted the area around the hominid tracks. Like previously unearthed tracks of three individuals who apparently strode across the same layer of soft ash at the same time, the latest footprints were probably made by members of Australopithecus afarensis, the team says. Best known for Lucy, a partial skeleton discovered in Ethiopia in 1974, A. afarensis inhabited East Africa from around 4 million to 3 million years ago.

All but one of the 14 hominid impressions come from the same individual. Based on footprint dimensions, the researchers estimate that this presumed adult male — nicknamed Chewie in honor of the outsized Star Wars character Chewbacca — stood about 5 feet 5 inches tall and weighed nearly 100 pounds. That makes him the tallest known A. afarensis. The team calculates that the remaining hominid footprint was probably made by a 4-foot-9-inch female who weighed roughly 87 pounds. Stature estimates based on the other three Laetoli footprint tracks fall below that of the ancient female.

Lucy lived later than the Laetoli crowd, around 3.2 million years ago, and was about 3 ½ feet tall.
If Laetoli’s five impression-makers were traveling together, “we can suppose that the Laetoli social group was similar to that of modern gorillas, with one large male and a harem of smaller females and perhaps juveniles,” says paleontologist and study coauthor Marco Cherin of the University of Perugia in Italy.

Chewie’s stature challenges a popular assumption that hominid body sizes abruptly increased with the emergence of the Homo genus, probably shortly after A. afarensis died out, Cherin adds.

The new paper presents reasonable stature estimates based on the Laetoli footprints, but “we don’t have a firm idea of how foot size was related to overall body size in Australopithecus,” says evolutionary biologist Kevin Hatala of Chatham University in Pittsburgh. Masao’s group referred to size data from present-day humans to calculate heights and weights of A. afarensis footprint-makers. That approach “could lead to some error,” Hatala says.

Stature estimates based on footprints face other obstacles, says paleoanthropologist Yohannes Haile-Selassie of the Cleveland Museum of Natural History. For instance, some tall individuals have small feet and short folks occasionally have long feet. It’s also unclear whether the new footprints and those from 1976 represent a single group, or if some smaller footprints were also made by males, Haile-Selassie adds. Cherin’s proposal that large A. afarensis males controlled female harems “is a bit of a stretch,” Haile-Selassie says.

The new report doesn’t document surprisingly large size differences among members of Lucy’s kind, Haile-Selassie adds. A. afarensis fossils previously excavated in Ethiopia include a partial male skeleton now estimated by Haile-Selassie and his colleagues to have been only about three inches shorter than Chewie’s reported height (SN: 7/17/10, p. 5).

A baby starfish scoops up snacks by spinning miniature whirlpools. These vortices catch tasty algae and draw them close so the larva can slurp them up, scientists from Stanford University report December 19 in Nature Physics.

Before starfish take on their familiar shape, they freely swim ocean waters as millimeter-sized larvae. To swim around on the hunt for food, the larvae paddle the water with hairlike appendages called cilia. But, the scientists found, starfish larvae also adjust the orientation of these cilia to fine-tune their food-grabbing vortices.

Scientists studied larvae of the bat star (Patiria miniata), a starfish found on the U.S. Pacific coast, by observing their activities in seawater suffused with tiny beads that traced the flow of liquid. (Watch a video of the experiment.) Too many swirls can slow a larva down, the scientists found, so the baby starfish adapts to the task at hand, creating fewer vortices while swimming and whipping up more of them when stopping to feed.

People hunted and foraged year-round in the thin air of China’s Tibetan Plateau at least 7,400 to 8,400 years ago, a new study suggests. And permanent settlers of the high-altitude region might even have arrived as early as 12,000 to 13,000 years ago.

Three lines of dating evidence indicate that humans occupied the central Tibetan Plateau’s Chusang site, located more than 4,000 meters above sea level, at least 2,200 years earlier than previously thought, say geologist Michael Meyer of the University of Innsbruck in Austria and colleagues. Their report, published in the Jan. 6 Science, challenges the idea that the Tibetan Plateau lacked permanent settlers until farming groups arrived around 5,200 years ago.、
“Hunter-gatherers permanently occupied the Tibetan Plateau by around 8,000 years ago, which coincided with a strong monsoon throughout Asia that created wet conditions on the plateau,” Meyer says.

These early permanent residents hunted animals such as wild yaks and foraged for edible plants, including berries from sea buckthorn shrubs, in nearby river valleys at elevations more than 3,600 meters above sea level, Meyer suspects. Brief, summer forays to Chusang would have been difficult for people living below 3,300 meters above sea level, he adds. Even when mountain passes were clear of heavy snowfall and expanding valley glaciers, round trips from low altitudes to the central Tibetan Plateau would have taken 41 to 70 days, Meyer’s team estimates.

Researchers discovered Chusang in 1998. The site consists of 19 human hand- and footprints on the surface of a fossilized sheet of travertine, a form of limestone deposited there by water from a hot spring.
The new age estimates for Chusang come from three measures: the decay rate of forms of radioactive thorium and uranium in travertine sampled in and around the prints; determinations of the time since quartz crystals extracted from the travertine were last exposed to sunlight; and radiocarbon measures of sediment and microscopic plant remains found on the travertine slab’s surface.
Signs of long-term camping at Chusang have yet to turn up, but extensive excavations of the site have not been conducted, Meyer says. His group found chipped rocks and other stone tool‒making debris at two spots near Chusang’s hot springs. These finds are undated.

Previous research has suggested that hunter-gatherers occasionally reached the Tibetan Plateau’s northern edge by around 12,000 years ago (SN: 7/7/01, p. 7), and again from about 8,000 to 6,000 years ago, says archaeologist Loukas Barton of the University of Pittsburgh, who wasn’t involved in the study. But the new discoveries at Chusang may not necessarily point to permanent residence there. Those early arrivals likely spent a single summer or a few consecutive years at most on the plateau, Barton says. “That would not constitute a peopling of a region any more than our 1969 visit to the moon did,” he says.

Archaeological finds indicate that human populations expanded on the Tibetan Plateau between around 5,200 and 3,600 years ago, Barton says. Those groups cultivated barley and wheat at high altitudes and herded domesticated sheep and perhaps yaks, he says.

Before that time, Chusang might have supported a year-round occupation, says archaeologist David Rhode of the Desert Research Institute in Reno, Nev., who wasn’t involved in the study. But the site could easily have been occupied seasonally, he says. Unlike Meyer, Rhode estimates that Chusang was about a two-week walk from some lower-altitude campsites. “That’s not far at all for a human forager.”

New dates for Chusang also raise the possibility that rare gene variants that aid survival in high-altitude, oxygen-poor locales first evolved among hunter-gatherers on the Tibetan Plateau, Meyer says. But both Barton and Rhode doubt it.

The part of the brain that governs emotions such as fear and anxiety also helps mice hunt. That structure, the amygdala, orchestrates a mouse’s ability to both stalk a cricket and deliver a fatal bite, scientists report January 12 in Cell.

Scientists made select nerve cells in mice’s brains sensitive to light, and then used lasers to activate specific groups of those cells. By turning different cells on and off, the researchers found two separate sets of nerve cells relaying hunting-related messages from the amygdala’s central nucleus. One set controlled the mice’s ability to chase their prey. The other affected their ability to deliver a solid chomp and kill a cricket.
“They’ve found these two behaviors — that are part of something we think of being very complex — are controlled by these two circuits,” says Cris Niell, a neuroscientist at the University of Oregon in Eugene who wasn’t part of the study. “You flip a switch to chase, you flip a switch to attack.”

Ramping both of those circuits up to high power at the same time even led mice to chase and capture a tiny bug-shaped robot that they would normally ignore or avoid.

“The central amygdala has been conceptualized as a center for emotion and fear and threat detection,” says study coauthor Ivan de Araujo, a neuroscientist at the John B. Pierce Laboratory in New Haven, Conn. Now, it seems that the structure also controls the relatively complex task of hunting.

Scientists don’t know how the new function relates to the amygdala’s better-known role as an emotional control center. But the amygdala does help control heart rate and blood pressure, which shift in emotionally charged situations but also need to be regulated when an animal is pursuing prey, de Araujo says.

The study also shows how even a complex task like hunting can be coordinated by different groups of very specialized nerve cells, or neurons, working together. In this case, one set of neurons made a signaling pathway that controlled chasing, while another controlled biting. Together, those neurons helped the mice grab dinner.
“I think over the years we’ve become progressively more surprised by the behavioral specificity of these particular pathways,” says Anthony Leonardo, a neuroscientist at the Howard Hughes Medical Institute’s Janelia Research Campus in Ashburn, Va. “Certainly the evidence is mounting for a very strongly specific role for neurons.” Leonardo has found similarly specialized neurons in the dragonfly brain, with groups of neurons that run in parallel to each other controlling different types of movements.

Next, de Araujo says, his lab hopes to figure out what flips the neural switches in a mouse’s brain — how seeing or smelling potential prey triggers the amygdala to send the critter after a meal.

Heroin cure works

[T]he drug methadone appears to have fulfilled its promise as an answer to heroin addiction. Some 276 hard-core New York addicts … have lost their habits and none have returned to heroin — a 100 percent success rating. Methadone, a synthetic narcotic, acts by blocking the euphoric effect of opiates. Addicts thus get nothing from heroin and feel no desire to take it. — Science News. February 4, 1967.

UPDATE:
The U.S. Food and Drug Administration approved methadone as a treatment for opiate addiction in 1972 but quickly recognized that it was no panacea. That same year, policy makers worried that methadone would produce addicts — as patients got high off the treatment itself (SN: 10/28/72, p. 277). Methadone can be deadly: In 2014, 3,400 people died of methadone overdoses. Although methadone is still used, drugs such as buprenorphine and naltrexone have joined the treatment arsenal for opiate addiction.

Electronic cigarettes may increase the risk of heart disease, researchers at UCLA report.

The team found that two risk factors for heart disease were elevated in 16 e-cigarette users compared with 18 nonsmokers.

“The pattern was spot-on” for what has been seen in heart attack patients and those with heart disease and diabetes, says cardiologist Holly Middlekauff, a coauthor of the study published online February 1 in JAMA Cardiology.

But because the study only looked at a small number of people, the results are not definitive — just two or three patients can skew results, John Ambrose, a cardiologist with the University of California, San Francisco cautions. Plus, he says, some of the e-cigarette users in the study used to smoke tobacco, which may have influenced the data.
Even so, Ambrose called the study interesting, noting that “the medical community just doesn’t have enough information” to figure out if e-cigarettes are dangerous.

E-cigarette users in the study had heartbeat patterns that indicated high levels of adrenaline — also known as epinephrine — in the heart, a sign of heart disease risk. Researchers also found signs of increased oxidative stress, an imbalance of certain protective molecules that can cause the hardening and narrowing of arteries.

Previous research has connected oxidative stress to e-cigarettes. The new study targeted where it might occur and how it could contribute to heart disease, says Aruni Bhatnagar of the American Heart Association Tobacco Regulation and Addiction Center based at the University of Louisville in Kentucky.

This study “adds to the case that there may be some residual harm associated with e-cigarettes,” says Bhatnagar, whose editorial on e-cigarettes and heart risk appears in the same issue of JAMA Cardiology.

Previous studies have linked e-cigarettes to lung inflammation (SN: 7/12/14, p. 20) and examined the toxicity of e-cigarette vapor (SN: 8/20/16, p. 12).
Nicotine, the addictive substance found in both tobacco and electronic cigarettes, is known to elevate adrenaline levels. To ensure that they were measuring the long-term effects of vaping and not just the presence of nicotine, the researchers had their subjects refrain from using e-cigarettes the day of the tests.

The findings are important, Middlekauff says, because they show that e-cigarette users’ hearts are in “flight or fight” mode all the time, not just when they are smoking.

The next step is to nail down exactly what in e-cigarettes is responsible for these effects on the heart, Middlekauff says. The researchers also want to compare e-cigarettes’ effects on the heart with tobacco cigarettes’.

“Electronic cigarettes aren’t harmless,” Middlekauff says. “They have real, measurable physiological effects and these physiological effects, at least the couple that we found, have been associated with heart disease.”