The world’s most minuscule machines operate on the molecular level and have won their creators the 2016 Nobel Prize in chemistry. The prize is shared between Jean-Pierre Sauvage of the University of Strasbourg in France, J. Fraser Stoddart of Northwestern University in Evanston, Ill., and Bernard Feringa of the University of Groningen in the Netherlands.
Sauvage and colleagues first linked two ring-shaped molecules together in 1983 to form a necklacelike chain. In 1991, Stoddart’s team created an atom-scale axle, paving the way to build molecular “muscles” and “elevators.” Through electrochemistry, Feringa and colleagues powered up the first light-powered molecular motor in 1999 and even designed a four-wheel drive, nano-sized car.
These fantastic machines have opened up the molecular world to manipulating and moving objects at the smallest levels imaginable. There are “endless opportunities,” Feringa said in a phone interview during the announcement ceremony.
Scaling up from one cell to many may have been a small step rather than a giant leap for early life on Earth. A single-celled organism closely related to animals controls its life cycle using a molecular toolkit much like the one animals use to give their cells different roles, scientists report October 13 in Developmental Cell.
“Animals are regarded as this very special branch, as in, there had to be so many innovations to be an animal,” says David Booth, a biologist at the University of California, Berkeley who wasn’t part of the study. But this research shows “a lot of the machinery was there millions of years before animals evolved.” Multicellular organisms need to be able to send messages between their cells and direct them to particular roles within the body. That requires a great deal of cell-to-cell coordination — something that unicellular organisms don’t have to deal with. But an amoeba (Capsaspora owczarzaki) employs many of those same tricks to switch its single-celled body between different life stages. That means that the earliest animals were probably “recycling mechanisms that were already present before,” says study coauthor Iñaki Ruiz-Trillo, a biologist at the Institute for Evolutionary Biology in Barcelona.
C. owczarzaki goes through three different life stages, acting independently in some stages and aggregating with other amoebas in others. Ruiz-Trillo and colleagues analyzed C. owczarzaki’s proteome — its complete set of proteins — during each life stage.
The amoeba made different amounts of its proteins in each life stage, the team found, suggesting that it was responding to new demands. But it went a step further, too, also shifting the way its proteins behaved during each stage.
Proteins can change their behavior by grabbing on to a molecular fragment called a phosphate ion. The phosphate ion’s effect depends on where it sticks to the protein and whether there are other phosphate ions stuck on nearby. C. owczarzaki showed distinct differences in the pattern of these phosphate add-ons between its three life stages. That parallels what’s seen in animals: Proteins in different organs within the same animal show similar modification differences.
The researchers also found changes in the molecules that control the protein modification process. Certain enzymes within a cell act like molecular concierges, helping phosphate ions latch on to proteins. The type of enzyme often determines where the ion sticks — and thus the effect it has. For instance, enzymes called tyrosine kinases often guide modifications that help multicellular organisms send messages between cells. Those enzymes aren’t thought to be widely used by single-celled species, says study coauthor Eduard Sabidó, a biologist at the Centre for Genomic Regulation in Barcelona. But C. owczarzaki uses these enzymes across all of its life stages, generating them in different quantities depending on the stage. Previous research showed that other single-celled organisms had the genes for tyrosine signaling, but this study shows how widely it’s actually used and how closely it’s linked to specific life changes, says Booth.
The shared molecular mechanisms suggest that the unicellular common ancestor of today’s animals and C. owczarzaki probably used these same tricks, too, paving the way for multicellular life. That’s not to say animals don’t get any credit, says Sabidó — they’ve expanded this toolkit further over time. But the perceived chasm between a simple single-celled existence and a complex multicellular one might not have required a flying leap to cross. “This gap,” Sabidó says, “maybe isn’t such a gap.”
To the bafflement of birders, yellow-shafted flickers (Colaptes auratus auratus) sometimes sport red or orange wing feathers.
Scientists have suggested that the birds, which inhabit eastern North America, might be products of genetic variation affecting the carotenoid pigments that produce their flight-feather colors. Alternatively, the birds might be hybrids from mixing with a subspecies that lives in the west, red-shafted flickers (Colaptes auratus cafer). Despite decades of study, no clear-cut explanation has emerged.
It turns out that diet may be to blame. Jocelyn Hudon of the Royal Alberta Museum in Canada and her colleagues tested the red flight feathers from two yellow-shafted flickers and found traces of rhodoxanthin, a deep red pigment found in plants, and a potential metabolite. This suggests that the birds’ bodies break down rhodoxanthin — a clue that the pigment enters the body through food. Spectral and biochemical tests of feathers from museum collections also point to rhodoxanthin and suggest that the pigment may mess with yellow carotenoid production as well.
Yellow-shafted flickers probably pick up the red pigment when they eat berries from invasive honeysuckle plants, which contain the ruby pigment and produce similar red hues in other birds, the researchers write October 12 in The Auk. The plants also happen to produce berries just around the time that flickers molt their flight feathers.
PASADENA, Calif. — The forecast on Pluto is clear with less than a 1 percent chance of clouds. Images from the New Horizons spacecraft show hints of what could be a few isolated clouds scattered around the dwarf planet, the first seen in otherwise clear skies.
Seven cloud candidates appear to hug the ground in images taken shortly after the probe buzzed by the planet in July 2015. Along the line where day turns to night, several isolated bright patches appear. These are consistent with clouds forming at sunset and sunrise, said mission head Alan Stern during an October 18 news conference at a meeting of the American Astronomical Society’s Division for Planetary Sciences.
If they are clouds, they’re probably made of ethane, acetylene or hydrogen cyanide, based on what researchers have learned about Pluto’s atmosphere — though they might not be clouds, just reflective splotches on the surface, Stern said. Without stereo imaging, it’s impossible to tell how high off the ground the patches are, or whether they’re in the sky at all. Since New Horizons isn’t returning to Pluto — it’s hurtling deep into the Kuiper belt — the spacecraft won’t be able to take another look at the cloud candidates and answer these questions. That will have to wait until another spacecraft goes back to orbit Pluto, Stern said.
The Schiaparelli Mars lander, missing in action since its October 19 descent, dinged the surface of the Red Planet. A black spot framed by dark rays of debris mark the lander’s final resting place, the European Space Agency reports online October 27. Its parachute, still attached to the rear heat shield, lies about 1.4 kilometers to the south, new images from the Mars Reconnaissance Orbiter show. The front heat shield, ejected about four minutes into the descent, sits roughly 1.4 kilometers to the east of the impact site.
Radio contact with Schiaparelli was lost about 50 seconds before its planned landing. Early analysis of data from the lander indicate that the parachute was jettisoned prematurely and that the landing rockets shut off just a few seconds after igniting. Engineers with ESA’s ExoMars mission are still analyzing that data to understand what went wrong.
Below most volcanoes, Earth packs some serious deep heat. Mount St. Helens is a standout exception, suggests a new study. Cold rock lurks under this active Washington volcano.
Using data from a seismic survey (that included setting off 23 explosions around the volcano), Steven Hansen, a geophysicist at the University of New Mexico, peeked 40 kilometers under Mount St. Helens. That’s where the Juan de Fuca tectonic plate releases fluids due to intense heat and pressure as it descends beneath the North American plate. Those fluids rise and trigger melting in the rock above, fueling an arc of volcanoes that line up like lights on a runway. All except for Mount St. Helens, which stands apart about 50 kilometers to the west. Still, Hansen and colleagues expected to see a heat source under Mount St. Helens, as seen at other volcanoes. Instead, thermal modeling revealed a wedge of a rock called serpentinite that’s too cool to be a volcano’s source of heat, the researchers report November 1 in Nature Communications. “This hasn’t really been seen below any active arc volcanoes before,” Hansen says.
This odd discovery helps show what the local crust-mantle boundary looks like, but raises another burning question: Where is Mount St. Helens’ heat source? Somewhere to the east, suggests Hansen. Exactly where, or how it reaches the volcano, remains a cold case.
Editor’s Note: this article was revised on January 4, 2017, to note how the Juan de Fuca tectonic plate fuels the chain of volcanoes.
It’s a familiar sight: Your mom or grandmother picks up a document and immediately holds it out at arm’s length to make out the small letters on the page, while simultaneously reaching for her reading glasses. As people age, their ability to see things close up often fades, a condition known as presbyopia. The eye can no longer focus light on the retina, focusing it instead just behind and causing poor close-up vision.
Many have thought that presbyopia was a consequence of living in an era in which people are overburdened by tasks that require frequently focusing in the near-field of vision. But perhaps not: A new study finds that if bonobos could read, they too would need glasses as they age.
Bonobos aren’t burdened with having to read tiny newsprint or letters on a mobile phone screen, but they do perform one task that regularly requires close focus: grooming. This behavior not only removes tiny bits of dirt and ectoparasites from the animals but also promotes social relationships. Most of the time, a bonobo grooms by putting its face within 20 centimeters of its partner and picking off the offending debris with its fingers. But older bonobos place their partner at arm’s length, probably because they can no longer see close up, researchers report November 7 in Current Biology.
For more than 40 years, researchers from Japan’s Kyoto University have studied wild bonobos in the Luo Scientific Reserve near a village called Wamba. Some researchers had noticed that older bonobos groomed differently than young ones, keeping their companions at arm’s length. Then in 2015, Heunglin Ryu of Kyoto University and colleagues decided to try to quantify this. Was it all older bonobos, or just some? They photographed 14 bonobos as they groomed, using the bonobos’ ear length and a ruler to determine grooming distance. Then they plotted out their data.
Grooming distance increased exponentially after a bonobo hit age 35, with the oldest bonobos, at age 45, keeping their partners around five times as far away as did young bonobos. A video of one bonobo taken in 2009 showed how her vision changed. When Ki was 29 years old, she placed his face 11.9 centimeters from her fingers as she plucked away at her partner. But at age 35, that had increased to 16.9 centimeters.
Scientists had reported anecdotes of older female chimpanzees (male chimps generally do not reach old age) that developed presbyopia. The bonobo finding combined with our own bad eyesight may indicate that presbyopia is a condition that dates to at least our most recent common ancestor.
As in humans, bad eyesight may come with a price for older bonobos. People who are farsighted often have trouble seeing in the dark. If that is also true for bonobos, they may have difficulty seeing in the low light of the rainforest canopy. Plus, if they are not able to groom others well, that may affect their social lives. Maybe they would benefit from reading glasses.
Global emissions of carbon dioxide won’t increase much in 2016 despite overall economic growth, newly released bookkeeping suggests. The result marks a three-year-long plateau in the amount of CO2 released by human activities, scientists from the Global Carbon Project report November 14 in Earth System Science Data.
The group’s projected rise in CO2 emissions of 0.2 percent for 2016 is far lower than the rapid emissions growth of around 2.3 percent annually on average from 2004 through 2013. Emissions increased by about 0.7 percent in 2014 over the previous year and remained largely flat in 2015.
China is largely responsible for the emissions slowdown, the researchers write. The country is the world’s largest carbon dioxide emitter and is projected to reduce its CO2 emissions by 0.5 percent this year.
SAN ANTONIO — The world’s earliest alphabet, inscribed on stone slabs at several Egyptian sites, was an early form of Hebrew, a controversial new analysis concludes.
Israelites living in Egypt transformed that civilization’s hieroglyphics into Hebrew 1.0 more than 3,800 years ago, at a time when the Old Testament describes Jews living in Egypt, says archaeologist and epigrapher Douglas Petrovich of Wilfrid Laurier University in Waterloo, Canada. Hebrew speakers seeking a way to communicate in writing with other Egyptian Jews simplified the pharaohs’ complex hieroglyphic writing system into 22 alphabetic letters, Petrovich proposed on November 17 at the annual meeting of the American Schools of Oriental Research. “There is a connection between ancient Egyptian texts and preserved alphabets,” Petrovich said.
That’s a highly controversial contention among scholars of the Bible and ancient civilizations. Many argue, despite what’s recounted in the Old Testament, that Israelites did not live in Egypt as long ago as proposed by Petrovich. Biblical dates for the Israelites’ stay in Egypt are unreliable, they say. Scholars have also generally assumed for more than 150 years that the oldest alphabetic script Petrovich studied could be based on any of a group of ancient Semitic languages. But not enough is known about those tongues to specify one language in particular. Petrovich’s Hebrew identification for the ancient inscriptions is starved for evidence, said biblical scholar and Semitic language specialist Christopher Rollston of George Washington University in Washington, D.C. There is no way to tell which of many Semitic languages are represented by the early alphabetic system, Rollston contended.
The origins of writing in different parts of the world — including that of the alphabet carved into the Egyptian slabs — have long stimulated scholarly debates (SN: 3/6/93, p. 152). A German scholar identified the ancient Egyptian writing as Hebrew in the 1920s. But he failed to identify many letters in the alphabet, leading to implausible translations that were rejected by researchers.
Petrovich says his big break came in January 2012. While conducting research at the Egyptian Museum in Cairo, he came across the word “Hebrews” in a text from 1874 B.C. that includes the earliest known alphabetic letter. According to the Old Testament, Israelites spent 434 years in Egypt, from 1876 B.C. to 1442 B.C. Petrovich then combined previous identifications of some letters in the ancient alphabet with his own identifications of disputed letters to peg the script as Hebrew. Armed with the entire fledgling alphabet, he translated 18 Hebrew inscriptions from three Egyptian sites.
Several biblical figures turn up in the translated inscriptions, including Joseph, who was sold into slavery by his half-brothers and then became a powerful political figure in Egypt, Joseph’s wife Asenath and Joseph’s son Manasseh, a leading figure in a turquoise-mining business that involved yearly trips to Egypt’s Sinai Peninsula. Moses, who led the Israelites out of Egypt, is also mentioned, Petrovich says.
One inscription, dated to 1834 B.C., translates as “Wine is more abundant than the daylight, than the baker, than a nobleman.” This statement probably meant that, at that time or shortly before, drink was plentiful, but food was scarce, Petrovich suspects. Israelites, including Joseph and his family, likely moved to Egypt during a time of famine, when Egyptians were building silos to store food, he suggests.
A book by Petrovich detailing his analyses of the ancient inscriptions will be published within the next few months. Petrovich says the book definitively shows that only an early version of Hebrew can make sense of the Egyptian inscriptions.
SAN ANTONIO — A roughly 3,000-year-old cemetery on Israel’s coast is providing an unprecedented look at burial practices of the Philistines, a mysterious population known from the Old Testament for having battled the Israelites.
Work at the Ashkelon cemetery from 2013 to 2016 has uncovered remains of at least 227 individuals, ranging from infants to older adults. Only a small section of the cemetery has been explored. Archaeologist and excavation director Adam Aja of the Harvard Semitic Museum estimates that approximately 1,200 people were interred there over a span of about 100 years. “For the first time, we have found a formal Philistine cemetery,” Aja said November 18 at the annual meeting of the American Schools of Oriental Research. Aja and his colleagues first announced having found the Philistine graveyard on July 10. He was among several researchers to present their latest findings about the cemetery at the meeting.
Despite the new discoveries, the geographic origins of the Philistines remain unknown, Aja said. It’s also unclear how early Philistines reached the Middle East or how much their culture changed by the time they started burying their dead at Ashkelon.
Philistine burial practices have been discussed and debated for about a century. Other ancient Philistine sites in Israel, also identified in ancient texts, have yielded individual graves and small-scale burial grounds.
At Ashkelon, the dead were interred in several ways. Most individuals were placed in shallow pits, often with pairs of jugs or storage containers near the bodies. Some pits contained a person’s remains that had been buried on top of one or more previously interred bodies. Bronze earrings, bracelets, rings and other jewelry adorn most skeletons of children and women. Several pit graves of male skeletons include ornamental beads or engraved stones.
One grave holds a set of iron arrows near a man’s hip. A quiver probably once held the arrows at the man’s side, Aja suggested. Researchers also uncovered ashes and bone fragments from six human cremations in sealed jars placed in pit graves.
At least eight stone burial chambers capped with stone slabs were also found. The largest chamber held skeletons of 23 individuals. These burial chambers were aligned in three rows that ran parallel to the coast, Aja said.
Tapered storage jars found in pit graves and burial chambers were influenced by pottery of the Canaanites, a nearby population along the Mediterranean coast, said team member Janling Fu of Harvard University.
Fu suspects the excavation is located at the cemetery’s edge. Considerable space between some burials suggests denser clusters of grave sites lie nearby, he proposed, raising the prospect of learning much more about how the Philistines treated their dead.
Although the excavation is in its early stages, it’s clear that Philistines buried at Ashkelon show signs of physiological stress, reported bioarchaeologist and team member Sherry Fox of Eastern Michigan University in Ypsilanti. Many individuals’ teeth have signs of growth interruptions caused by fever, malnutrition or a range of possible biological disorders, she said.
Relatively short average heights for people buried at Ashkelon — about 5 feet, 1 inch for men and 4 feet, 10 inches for women — also fit a scenario of biological stress, Fox said. Short stature and minimal height differences between men and women occur with population-wide stresses such as malnutrition, she said.
The Philistines were a famously combative crowd. Archaeologist Eric Meyers of Duke University, who was not a member of the Ashkelon team, wondered if at least some of those buried at Ashkelon had been killed in battles or fights. But no head injuries or other skeletal signs of violent encounters appeared among the dead at Ashkelon, Fox said. Neither did any skeletons contain evidence of tumors or cancers.
If DNA can be extracted from the Ashkelon skeletons, scientists may get a glimpse of where the Philistines originally came from. Evolutionary geneticist Johannes Krause of the Max Planck Institute for the Science of Human History in Jena, Germany, is currently directing efforts to retrieve genetic sequences from the Ashkelon bones.
